Generic Name: gadobenate dimeglumine (GAD oh BEN ate dye MEG loo meen)
Brand Names: Multihance
What is Multihance (gadobenate dimeglumine)?
Gadobenate dimeglumine is a contrast agent that produces magnetic effects. It is used in combination with magnetic resonance imaging (MRI) to allow blood vessels, organs, and other non-bony tissues to be seen more clearly on the MRI.
Gadobenate dimeglumine is used to help diagnose certain disorders of the brain and spine (central nervous system).
Gadobenate dimeglumine may also be used for purposes not listed in this medication guide.
What is the most important information I should know about Multihance (gadobenate dimeglumine)?
Gadobenate dimeglumine can cause a life-threatening condition in people with advanced kidney disease. The symptoms of this condition include:
burning, itching, swelling, scaling, and tightening or hardening of your skin;
muscle weakness;
joint stiffness in your arms, hands, legs, or feet;
deep bone pain in your ribs or your hips;
trouble moving; or
skin redness or discoloration.
Before receiving this medication, tell your doctor if you have kidney disease or if you are on dialysis. You may not be able to receive gadobenate dimeglumine.
Also tell your doctor if you have diabetes, high blood pressure, liver disease (or liver transplant), a heart rhythm disorder, a personal or family history of "Long QT Syndrome," asthma or allergies, a history of seizures, a genetic bilirubin disorder (Dubin Johnson syndrome), if you are over 60 years old, if you have ever had a reaction to a contrast agent, or if you have recently had an injury, surgery, or severe infection.
Your doctor or other healthcare provider may want to watch you for a short time after your test is over. This is to make sure you do not have any unwanted side effects or delayed reactions.
What should I discuss with my healthcare provider before receiving Multihance (gadobenate dimeglumine)?
Gadobenate dimeglumine can cause a life-threatening condition in people with advanced kidney disease. The symptoms of this condition include:
burning, itching, swelling, scaling, and tightening or hardening of your skin;
muscle weakness;
joint stiffness in your arms, hands, legs, or feet;
deep bone pain in your ribs or your hips;
trouble moving; or
skin redness or discoloration.
Before receiving this medication, tell your doctor if you have kidney disease or if you are on dialysis. You may not be able to receive gadobenate dimeglumine.
To make sure you can safely receive this medication, tell your doctor if you have any of these other conditions:
diabetes;
high blood pressure;
liver disease (or liver transplant);
a heart rhythm disorder;
a personal or family history of "Long QT Syndrome";
asthma, hay fever, or a history of food or drug allergies;
a history of seizures;
a genetic bilirubin disorder called Dubin Johnson syndrome (chronic jaundice);
if you are over 60 years old;
if you have ever had any type of reaction to a contrast agent; or
if you have recently had an injury, surgery, or severe infection.
FDA pregnancy category C. It is not known whether gadobenate dimeglumine will harm an unborn baby. Before you receive this medication, tell your doctor if you are pregnant. It is not known whether gadobenate dimeglumine passes into breast milk or if it could harm a nursing baby. Do not breast-feed for at least 24 hours after receiving gadobenate dimeglumine. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby.
How should I take Multihance (gadobenate dimeglumine)?
Gadobenate dimeglumine is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting during your MRI.
Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when the medicine is injected.
Your doctor or other healthcare provider may want to watch you for a short time after your test is over. This is to make sure you do not have any unwanted side effects or delayed reactions.
See also: Multihance dosage (in more detail)
What happens if I miss a dose?
Since gadobenate dimeglumine is used only during your MRI, you will not be on a dosing schedule.
What happens if I overdose?
Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid after receiving Multihance (gadobenate dimeglumine)?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Multihance (gadobenate dimeglumine) side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:
urinating less than usual or not at all;
drowsiness, confusion, mood changes, increased thirst, loss of appetite;
swelling, weight gain, feeling short of breath;
seizure (convulsions);
fast, uneven heart rate; or
pain, burning, swelling, blistering, or skin changes where the injection was given (may occur up to several days after injection).
Less serious side effects may include:
headache, dizziness;
nausea, vomiting;
fever, sweating, feeling unusually hot;
unusual or unpleasant taste in your mouth;
mild skin rash; or
numbness, burning pain, or tingling in your hands or feet;
cold feeling, warmth, pain, or bruising where the medicine was injected.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Multihance (gadobenate dimeglumine)?
This medication can harm the kidneys in certain people, and this effect may be increased if you also use other medicines harmful to the kidneys. Many other drugs (including some over-the-counter medicines) can harm your kidneys. Tell your doctor if you are receiving chemotherapy, or using antiviral medication, pain or arthritis medicine, any injected antibiotics, or medicines to treat a bowel disorder or prevent organ transplant rejection. You may need dose adjustments or special tests if you have recently used any of these medications.
Tell your doctor about all other medicines you use, especially:
cisplatin (Platinol);
daunorubicin (Daunoxome, Cerubidine);
docetaxel (Docefrez, Taxotere);
doxorubicin (Adriamycin, Doxil);
epirubicin (Ellence);
etoposide (Etopophos, Toposar, VePesid);
methotrexate (Rheumatrex, Trexall);
paclitaxel (Taxol, Abraxane);
rifampin (Rifater, Rifadin, Rifamate);
tamoxifen (Soltamox);
vinblastine (Velban), vincristine (Oncovin, Vincasar), vinorelbine (Navelbine);
heart or blood pressure medicine such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Dutoprol, Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others; or
HIV or AIDS medication such as atazanavir (Reyataz), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (VIracept), ritonavir (Norvir, Kaletra) or saquinavir (Invirase).
There may be other drugs that can affect gadobenate dimeglumine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
More Multihance resources
- Multihance Side Effects (in more detail)
- Multihance Dosage
- Multihance Use in Pregnancy & Breastfeeding
- Multihance Drug Interactions
- Multihance Support Group
- 0 Reviews for Multihance - Add your own review/rating
- Multihance Advanced Consumer (Micromedex) - Includes Dosage Information
- Gadobenate Dimeglumine Professional Patient Advice (Wolters Kluwer)
- MultiHance Prescribing Information (FDA)
Compare Multihance with other medications
- CNS Magnetic Resonance Imaging
Where can I get more information?
- Your doctor or pharmacist can provide more information about gadobenate dimeglumine.
See also: Multihance side effects (in more detail)
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